Worldwide, Non-Typhoid Salmonella is a severe public health problem especially in Africa with high disease burden. This study characterizes various human Salmonella isolates to determine the phage types, serotype distribution and antimicrobial resistance and the clonal relatedness among these isolates. Twenty-two serovars were identified with S. Enteritis, S. Typhimurium, and Salmonella Derby being the most dominant. 112 isolates showed resistance to more than one antimicrobial. 58 strains were multi-resistant with low resistance to cephalosporin, ceftazidime, cefotaxime, and cefoxitin with synergy to clavulanic acid indicating possible ESBLs. Isolates showed high resistance to trimethoprim, tetracycline, ampicillin, sulfamethoxazole, chloramphenicol, and ciprofloxacin.