Diagnosis and treatment of ovarian cancer

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Most ovarian carcinomas are epithelial (90%) with histological subtypes including serous (35%), endometrioid (10%), borderline(16%), mucinous (8%), clear cell (4%), undifferentiated and mixed epithelial. In general, the prognosis of ovarian carcinomas depends on the FIGO stage, tumour grade, histological subtype, age and the volume of residual disease after surgery, however, for stage I tumours the most important prognostic indicators are considered to be the degree of differentiation(grade) and the occurrence of tumour rupture. On the aspect of surgical treatment, the standard management of women with ovarian cancer is comprehensive surgical staging by laparotomy, a midline abdominal incision that allows exposure of the entire abdomen. Comprehensive surgical staging includes a total hysterectomy, bilateral salpingo-oophorectomy, removal of the entire obvious sites of tumour, aspiration of cytological washings or ascites, omentectomy, retroperitoneal(pelvic and para-aortic) lymph node dissection or sampling and biopsy of all suspicious-looking areas including mesentery, liver and diaphragm.

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Kulcsszavak
CA -125 markers, HE-4 markers, Fertility-sparing surgery, Debulking surgery
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