The aim of this thesis is to give a broad prospective regarding the role of fluoride in the prevention of dental caries. Introduce the most common fluoride compounds and present the systemic and topical either self-or professionally used fluoridation methods. Fluoride is most effective when a constant low level is maintained over an extended period in the oral cavity. Over time, fluoride becomes available in the plaque, oral fluids and the tooth's hard tissue, where it acts as a reservoir for remineralization, increase the resistance to acid attacks and inhibits cariogenic bacteria.