Psoriasis is a complicated illness that affects people of all ages all over the world. The chronic nature of the skin condition frequently puts the patient's psychological and social well-being at risk. With numerous comorbidities associated with psoriasis, effective therapy must be begun as soon as possible. Because of varying ages of onset, types of symptoms, regions of involvement, and disease severity, the clinical presentation of persistent plaque psoriasis can vary greatly across patients, necessitating a holistic and individualized approach to therapy while keeping the patient's needs in mind.