The use of oral probiotics has garnered more attention during the last several decades. Nevertheless, it is vital to understand that each of the suggested health advantages must be individually investigated for each bacterial strain. It seems that the oral microbiota as well as immune responses are influenced by probiotic bacteria. It has been demonstrated that different species of probiotic bacteria can improve periodontal health in humans through a variety of mechanisms. Some of these processes include manipulation of the host immune system as well as competition and suppression of the development, biofilm formation, and virulence expression of periodontopathogens.