The effect of tankyrase inhibitors on the adipocyte cell differentiation

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dc.contributor.advisorBay, Péter
dc.contributor.authorKurmanbaev, Daniela
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézethu_HU
dc.date.accessioned2021-11-22T08:30:01Z
dc.date.available2021-11-22T08:30:01Z
dc.date.created2021-11-18
dc.description.abstractThere is an increasing number of people suffering from obesity and diabetes all around the world increase the number of metabolic disease cases such as type 2 diabetes, cardiovascular disease, and even cancer. Recently, TNKS enzymes were identified to play role in metabolic regulation and energy homeostasis and regulate the translocation of Glut4, thus playing a critical role in glucose metabolism. The project aims to investigate how the inhibition of tankyrase affects the differentiation between white, brown, and beige adipocytes utilizing pharmacological inhibitors. To obtain the results we examine the assessment of tankyrase's role in white adipose tissue differentiation and function. We used 3T3-L1 preadipocite cells (mouse origin) as model for white adipose tissue differentiation. As a result, the TNKS1 gene was knockout from T1 cell lines. In further work, we will use that T1 cell line to generate double KO cells.hu_HU
dc.description.correctorhbk
dc.description.courseBiochemical Engineeringhu_HU
dc.description.degreeBSc/BAhu_HU
dc.format.extent32hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/325234
dc.language.isoenhu_HU
dc.subjecttankyrase inhibitorshu_HU
dc.subjectTankyrasehu_HU
dc.subjectPARPhu_HU
dc.subjectWhite Adipose Tissuehu_HU
dc.subjectBrown Adipose Tissuehu_HU
dc.subjectadipocyteshu_HU
dc.subjectcell differentiationhu_HU
dc.subjectUncoupling Protein 1hu_HU
dc.subjectobesityhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.subject.dspaceDEENK Témalista::Biológiai tudományokhu_HU
dc.subject.dspaceDEENK Témalista::Kémiahu_HU
dc.titleThe effect of tankyrase inhibitors on the adipocyte cell differentiationhu_HU
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