Antibiotics and Drug Induced Liver Injury

A tétel rövid nézete
dc.contributor.advisorMegyeri, Attila
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorKore, Vaishnavee Umesh
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentHalasi, Barbara Dóra
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Igazságügyi Orvostani Intézet
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.date.accessioned2023-05-03T08:24:36Z
dc.date.available2023-05-03T08:24:36Z
dc.date.created2023-02-22
dc.description.abstractDrug-induced liver injury (DILI) is hepatotoxicity caused by therapeutic drugs or other noninfectious toxins. Antibiotics are etiologically the most common causes of DILI, so they are the main focus of this thesis. The aim of this thesis is to review the literature and identify the most important causes of drug induced liver injury (DILI), classify the clinical features of injury caused by antibiotics, and identify risk factors to raise the index of suspicion of DILI in susceptible patients. To successfully do this, the interaction between the liver and xenobiotics in general should be clear, the pathomechanism of injury must be explained, as well as the possible phenotypes that can present, as well as which drugs can be suspected in such cases. The management most commonly involves withdrawing the drug and the disease is usually self-limiting upon withdrawal.
dc.description.correctorLB
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent36
dc.identifier.urihttps://hdl.handle.net/2437/351551
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectAntibiotics
dc.subjectLiver
dc.subjectDILI
dc.subjectIdiosyncratic
dc.subjectAmoxicillin
dc.subjectnitrofurantoin
dc.subjectisoniazid
dc.subjectminocycline
dc.subjecthepatotoxicity
dc.subjecttrimethoprim/sulfamethoxazole
dc.subjectcefazolin
dc.subjectciprofloxacin
dc.subjectlevofloxacin
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológia
dc.titleAntibiotics and Drug Induced Liver Injury
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Gyűjtemények
Theses (Faculty of Medicine)