Drug-induced liver injury (DILI) is hepatotoxicity caused by therapeutic drugs or other noninfectious toxins. Antibiotics are etiologically the most common causes of DILI, so they are the main focus of this thesis. The aim of this thesis is to review the literature and identify the most important causes of drug induced liver injury (DILI), classify the clinical features of injury caused by antibiotics, and identify risk factors to raise the index of suspicion of DILI in susceptible patients. To successfully do this, the interaction between the liver and xenobiotics in general should be clear, the pathomechanism of injury must be explained, as well as the possible phenotypes that can present, as well as which drugs can be suspected in such cases. The management most commonly involves withdrawing the drug and the disease is usually self-limiting upon withdrawal.