[S] Very young and advanced maternal age strongly elevates the occurrence of nonchromosomal congenital anomalies: a systematic review and meta-analysis of population-based studies

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dc.contributor.authorPethő, Boglárka
dc.contributor.authorVáncsa, Szilárd
dc.contributor.authorVáradi, Alex
dc.contributor.authorAgócs, Gergely
dc.contributor.authorMátrai, Ákos
dc.contributor.authorZászkaliczky-Iker, Franciska
dc.contributor.authorBalogh, Zita
dc.contributor.authorBánhidy, Ferenc
dc.contributor.authorHegyi, Péter
dc.contributor.authorÁcs, Nándor
dc.contributor.authorVáradi Alex (1991-) (biológus)
dc.contributor.submitterdepDE - Metagenomikai Intézet
dc.date.accessioned2024-09-09T07:27:49Z
dc.date.available2024-09-09T07:27:49Z
dc.date.oa2024-09-17
dc.date.updated2024-09-09T07:27:49Z
dc.description.abstractBackground: Nonchromosomal congenital anomalies (NCAs) are the most common cause of infant mortality and morbidity. The role of maternal age is well known, although the specifics are not thoroughly elucidated in the literature. Objective: To evaluate the role of maternal age in the incidence of NCAs and to pinpoint age groups at higher risk to refine screening protocols. Study Design: A systematic review and meta-analysis were conducted following the PRISMA 2020 guidelines and Cochrane Handbook. Searches were performed on October 19, 2021, across MEDLINE (via PubMed), Cochrane Library (CENTRAL), and Embase. Population-based studies assessing the impact of maternal age on the incidence of NCAs in pregnant women were included, without restrictions on age range, country, or comorbidities. A random-effects model was used for pooling effect sizes, considering the heterogeneity across studies. Results: From 15,547 studies, 72 were synthesized. Maternal age >35 showed an increased NCA risk (risk ratio [RR]: 1.31, confidence interval [CI]: 1.07 -1.61), rising notably after>40 (RR: 1.44, CI: 1.25 -1.66). The latter changes to 1.25 (CI: 1.08 -1.46) if the co-occurrence of chromosomal aberrations is excluded. Specific anomalies like cleft lip/palate (>40, RR: 1.57, CI: 1.11 -2.20) and circulatory system defects (>40, RR: 1.94, CI: 1.28 -2.93) were significantly associated with advanced maternal age. Conversely, gastroschisis was linked to mothers <20 (RR: 3.08, CI: 2.74 -3.47). Conclusion: The study confirms that both very young and advanced maternal ages significantly increase the risk of NCAs. There is a pressing need for age-specific prenatal screening protocols to better detect these anomalies, especially considering the current trend of delayed childbearing. Further research is required to fully understand the impact of maternal age on the prevalence of rarer NCAs. © 2024 The Author(s)
dc.description.correctorTCS
dc.identifier.citationAmerican Journal Of Obstetrics And Gynecology. -2024 (2024), p. p. 1-84. -Am. J. Obstet. Gynecol. -0002-9378
dc.identifier.doi10.1016/j.ajog.2024.05.010
dc.identifier.issn0002-9378
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM123848
dc.identifier.urihttps://hdl.handle.net/2437/379926
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0002937824005921
dc.languageeng
dc.rights.accessopen access article
dc.rights.ownerszerző
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.subject.otheraging
dc.subject.othercongenital abnormalities
dc.subject.othermaternal age
dc.subject.othernonchromosomal anomalies
dc.subject.otherpregnancy
dc.subject.otherscreening
dc.title[S] Very young and advanced maternal age strongly elevates the occurrence of nonchromosomal congenital anomalies: a systematic review and meta-analysis of population-based studies
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