Measuring the exosomal microRNA changes in hematology and oncology patients suffering by invasive aspergillosis

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dc.contributor.advisorPaholcsek, Melinda
dc.contributor.advisordeptDebreceni Egyetem::Mezőgazdaság-, Élelmiszertudományi és Környezetgazdálkodási Kar
dc.contributor.authorHossain, Syed Akib
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentJambrovics, Károly
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Biokémiai és Molekuláris Biológiai Intézet
dc.date.accessioned2023-06-15T11:35:24Z
dc.date.available2023-06-15T11:35:24Z
dc.date.created2023-05-02
dc.description.abstractThis study aimed to compare the alterations on expression patterns of exosomal microRNAs between invasive aspergillosis patients and healthy controls. A small experimental study was designed to measure the expression rate of 14 different exosomal microRNAs in different patient groups which might be linked to invasive fungal infections. Among them, 9 different microRNAs were significantly down-regulated in proven (P1) and probable (P2) cases in comparison to possible (P3) controls. Diagnostic performance of exosomal microRNA biomarkers were evaluated with different combinations of differentially expressed exosomal microRNAs. In summary, this experimental approach showed the differential expression of exosomal microRNAs which might be involved in invasive aspergillosis pathogenesis and can also serve as diagnostic biomarkers for early detection of IA and its treatment.
dc.description.correctorLB
dc.description.coursemolekuláris biológia
dc.description.courselangangol
dc.description.coursespecBiokémia-genomika
dc.description.degreeMSc/MA
dc.format.extent38
dc.identifier.urihttps://hdl.handle.net/2437/355680
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectInvasive Aspergillosis
dc.subjectExosome
dc.subjectmicroRNA
dc.subjectBiomarker
dc.subject.dspaceDEENK Témalista::Biológiai tudományok::Genetika
dc.titleMeasuring the exosomal microRNA changes in hematology and oncology patients suffering by invasive aspergillosis
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Theses (Faculty of Medicine)