Endothelial dysfunction from a pharmacological point of view

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorAli, Bashar Abed Alfattah Dyab
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2020-02-04T11:18:44Z
dc.date.available2020-02-04T11:18:44Z
dc.date.created2019
dc.description.abstractEndothelial cells that line the internal surface of the vasculature are a major regulator of vascular tone, inflammation, coagulation and platelet function. Endothelium exerts its effect by synthetize, metabolize and release numerous substances that regulates vascular homeostasis including endothelial derived hyperpolarizing factor, prostacyclin, thromboxane A2, kinins, adrenomedullin, angiotensin II, endothelin and nitric oxide. Endothelial dysfunction occurs when there is a disturbance of vascular homeostatic mechanism and impairment of endothelial derived vasorelaxation. Among the several pathomechanisms that are responsible for the endothelial dysfunction, oxidative stress, inflammation and the reduction of nitric oxide bioavailability are the most important mechanisms. A Varity of risk factors play a critical role in the development of endothelial dysfunction for example hypercholesterolemia, hyperhomocysteinemia, diabetes mellitus and smoking. Many investigational and currently used drugs have a beneficial effect on endothelial cells through variable mechanisms, mainly through their antioxidant and antiinflammatory effects. Several drugs which are used for cardiovascular diseases appears to have a protective effect on endothelial cells. The main focus of this review will be on endotheliumderived vasoactive substances, risk factors and some pharmacological substances that can improve endothelial function.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent58hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/280306
dc.language.isoenhu_HU
dc.subjectendothelial dysfunctionhu_HU
dc.subjectendotheliumhu_HU
dc.subjectvascular homeostasishu_HU
dc.subjectatherosclerosishu_HU
dc.subjectnitric oxidehu_HU
dc.subjectvascular diseasehu_HU
dc.subjectvasoactive substanceshu_HU
dc.subjectvasodilationhu_HU
dc.subjectvasoconstrictionhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Farmakológiahu_HU
dc.titleEndothelial dysfunction from a pharmacological point of viewhu_HU
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