Complex Therapy of Osteoporosis in Postmenopausal Women

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDepartment of Pharmacology and Pharmacotherapyhu_HU
dc.contributor.authorNguyen, Thao
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDepartment of Pharmacology and Pharmacotherapyhu_HU
dc.contributor.opponentdeptKenézy Kórház Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.date.accessioned2020-02-21T11:11:04Z
dc.date.available2020-02-21T11:11:04Z
dc.date.created2019-05
dc.description.abstractOsteoporosis, which is specifically common among postmenopausal women, is a worldwide major healthcare problem. Etiologies of postmenopausal osteoporosis include hormonal, nutritional, mechanical and toxic causes. Postmenopausal osteoporosis remarkably increases the risk of fractures. Osteoporotic fractures, especially spine and hip fractures, lead to impairments of mobility and vital functions, consequently are associated with high morbidity and mortality in postmenopausal women. Therefore, the primary goal of osteoporosis therapy is prevention of fractures. Osteoporotic fractures occur due to qualitative and quantitative deterioration in trabecular and cortical bone. Preventing fractures can be accomplished by stopping or decelerating bone loss, preserve bone strength, and minimizing factors contributing to fractures. Management of postmenopausal osteoporosis requires a thorough patient evaluation, including careful history taking, physical examinations, and laboratory tests, thereby physicians can make a risk assessment and guide the therapeutic decisions. Therapy of postmenopausal osteoporosis starts with general measures, such as maintaining mobility and fall prevention, a balanced diet, and adequate calcium, vitamin D and vitamin K2 intake. If additional pharmacological therapy is indicated, many effective treatments are available. Osteoporotic pharmacological therapy is classified as antiresorptive agents (e.g. bisphosphonates, selective estrogen-receptor modulators, parathyroid hormone, denosumab, estrogens, and vitamin D derivatives), and anabolic agents (e.g. teriparatide). Combination therapy including the concomitant or sequential use of agents may also provide protective benefits.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.coursespecOrvosbiológia-farmakológiahu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent50hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/281041
dc.language.isoenhu_HU
dc.subjectComplex Therapyhu_HU
dc.subjectOsteoporosishu_HU
dc.subjectPostmenopausal Womenhu_HU
dc.subjectVitamin Dhu_HU
dc.subjectBisphosphonatehu_HU
dc.subjectCalciumhu_HU
dc.subjectVitamin K2hu_HU
dc.subjectSelective estrogen-receptor modulatorshu_HU
dc.subjectSERMhu_HU
dc.subjectParathyroid Hormonehu_HU
dc.subjectPTHhu_HU
dc.subjectDenosumabhu_HU
dc.subjectCombination Therapieshu_HU
dc.subjectMenopausal Hormone Therapyhu_HU
dc.subjectVitamin D Derivativeshu_HU
dc.subjectMobilityhu_HU
dc.subjectFall Preventionhu_HU
dc.subjectTeriparatidehu_HU
dc.subjectalendronatehu_HU
dc.subjectrisedronatehu_HU
dc.subjectibandronatehu_HU
dc.subjectzoledronic acidhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Gyógyszerésztudományhu_HU
dc.titleComplex Therapy of Osteoporosis in Postmenopausal Womenhu_HU
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