A review of the study of the effectiveness of drug candidate BGP-15 in delaying diastolic dysfunction in the Goto-Kakizaki rat model of diabetic cardiomyopathy

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Review of a current study to compare the drug candidate, BGP-15, to metformin and pioglitazone. The aim was to observe whether BGP-15 had any cardiovascular effects on Goto-Kakizaki (GotoK) rats. The reason for this is to find an alternative, enhanced treatment for diabetic cardiomyopathy that has a better side effect profile and is more effective than current antidiabetic medication. In the study, BGP-15 was found to restore diastolic function in GotoK rats. Metformin and pioglitazone had no significant effect on echocardiographic parameters.

BGP-15, Diastolic dysfunction