The aim of this study is to investigate the effect of surface roughness and chemical composition of polymerized resin composites of wetting of water, organic solvents (acetone, ethanol), and aqueous solution of phosphoric acid (37 m/m% H₃PO₄). The tested composites were Estelite Asteria (EA), Clearfil Majesty (CM), Enamel Plus Hri Bio Function (EBF), EverX (EX), NeoSpectra (NS), Smart Dentin Replacement (SDR), and Tetric EvoCeram Bulk Fill composite (TECBF). The highest CA was found by H3PO4, then water, due to structure making effect of the acid. The lowest CA was found with acetone, then ethanol. The wettability of resin-rich composite is more preferable for acetone than ethanol, explained by the polarity of the organic solvent molecule. The Ra and composition of resin had no effect on wetting, except for SDR and TECBF due to the size of filler particles and prepolymers, respectively.