Pharmacological management of PCOS

Huang, Chi
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Kötet címe (évfolyam száma)
Polycystic ovary syndrome is a complex disorder that requires multiple treatment approaches. PCOS is characterized by hyperandrogenism, menstrual dysfunction, impaired fertility and polycystic ovaries. The first-line treatment for PCOS is lifestyle modifications and weight loss. However, most patients require pharmacological interventions to achieve more desirable outcomes. Common treatment targets include anovulation and androgenic syndromes. For ovulation induction, clomiphene, antidiabetic agents, gonadotropins and aromatase inhibitors are routinely used. Antiandrogens and oral contraceptives are frequently prescribed for androgenic syndromes, depending on whether the patient wishes to conceive or not. If the patient does not wish to conceive, oral contraceptives are the treatment of choice. Besides the drugs mentioned above, there are multiple drugs used in the treatment of PCOS, for example, medroxyprogesterone, antidepressants and statins. Since PCOS is the most prevalent endocrinopathy among women in reproductive age, researchers are working on various new drug targets to maximize treatment outcome. Potential new drug targets include aquaporin modulators, vitamin D and omega-3 supplementation, isotretinoin and traditional Chinese medicine.