Effect of Competition of Nuclear Receptors in Phosphate-Mediated Ectopic Calcification in Calcific Aortic Valve Disease

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dc.contributor.advisorGyƶrgy, VƔmosi
dc.contributor.advisorArpan, Chowdhury
dc.contributor.advisordeptƁltalĆ”nos OrvostudomĆ”nyi Kar::Biofizikai Ć©s SejtbiolĆ³giai IntĆ©zet
dc.contributor.authorMerazga , Rim
dc.contributor.departmentDE--ƁltalƔnos OrvostudomƔnyi Kar
dc.contributor.opponentJambrovics, KƔroly
dc.contributor.opponentdeptƁltalĆ”nos OrvostudomĆ”nyi Kar::BiokĆ©miai Ć©s MolekulĆ”ris BiolĆ³giai IntĆ©zet
dc.date.accessioned2025-06-04T11:47:43Z
dc.date.available2025-06-04T11:47:43Z
dc.date.created2025-04-30
dc.description.abstractBone calcification is a physiological process where calcium salts are deposited within collagen fibers in bones and teeth in the form of hydroxyapatite crystals. However, under pathological conditions such as chronic kidney disease (CKD), calcium salts accumulate and deposit in soft tissues ( such as the brain, eyes, and heart ) in a process called ectopic calcification. This abnormal biomineralization, which is driven by hyperphosphatemia and hypocalcemia, poses serious health risks, including cardiovascular complications like calcific aortic valve disease (CAVD). Vitamin D, another known inducer of calcification, is generally used as a supplement during CKD to maintain bone health. Vitamin D receptor (VDR) needs to heterodimerize with Retinoid X Receptor (RXR) for its function, like some other nuclear receptors (NRs) such as Peroxisome Proliferator-Activated Receptor Gamma (PPARĪ³), Retinoic Acid Receptor (RAR), etc. It is also proven that nuclear receptors compete for heterodimerization with RXR in a ligand-dependent manner. Based on the above-mentioned information, we ask whether VDR agonist induces aortic valve calcification? And if agonists of other NRs (RAR, PPARĪ³) influence this process?
dc.description.coursemolekulĆ”ris biolĆ³gia
dc.description.courselangangol
dc.description.coursespecBiokƩmia-genomika
dc.description.degreeMSc/MA
dc.format.extent39
dc.identifier.urihttps://hdl.handle.net/2437/390851
dc.language.isoen
dc.rights.infoHozzĆ”fĆ©rhető a 2022 decemberi felsőoktatĆ”si tƶrvĆ©nymĆ³dosĆ­tĆ”s Ć©rtelmĆ©ben.
dc.subjectCalcific aortic valve disease
dc.subjectNuclear receptors competition
dc.subjectVitamin D receptor
dc.subject.dspaceBiology
dc.subject.dspaceChemistry
dc.titleEffect of Competition of Nuclear Receptors in Phosphate-Mediated Ectopic Calcification in Calcific Aortic Valve Disease
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