The immunomodulatory effects of ivermectin on human monocyte-derived dendritic cells

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dc.contributor.advisorBacsi, Attila
dc.contributor.advisorVarga, Aliz
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Immunológiai Intézet
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Immunológiai Intézet
dc.contributor.authorAl-Bayati, Ibrahim Faisal Ibrahim
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentSzalmas, Anita
dc.contributor.opponentdeptÁltalános Orvostudományi Kar::Orvosi Mikrobiológiai Intézet
dc.date.accessioned2024-05-31T08:38:57Z
dc.date.available2024-05-31T08:38:57Z
dc.date.created2024-04-25
dc.description.abstractIvermectin, a drug used to treat parasitic infections, has gained attention for its possible immune system-modulating effects beyond its usual medical applications. This research aims to investigate the effect of ivermectin as immunomodulatory through its impact on moDCs by studying the amount of HLA-DQ molecules and CD86 molecules on moDCs by flow cytometry and their production of proinflammatory cytokines (IL-6 and TNF-a) by ELISA, by analysing the impacts of different treatments (control, DMSO, ivermectin, pIC+DMSO, pIC+LyoVec+DMSO, pIC+Ivermectin, pIC+LyoVec+Ivermectin) on moDCs and their role in immune regulation during viral infections. The results, meticulously obtained through the flow cytometry method, revealed no significant differences in cell vitality under various experimental conditions. This indicates that the concentration of 2.5 micromolar, whether used alone or in combination with other treatments, did not exhibit any toxic effects on the cells, reinforcing the safety of the experimental setup.
dc.description.coursemolekuláris biológia
dc.description.courselangangol
dc.description.coursespecImmunológia, sejt- és mikrobiológia
dc.description.degreeMSc/MA
dc.format.extent44
dc.identifier.urihttps://hdl.handle.net/2437/370694
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectmonocyte-derived dendritic cells
dc.subjectivermectin
dc.subjectELISA
dc.subjectflow cytometry
dc.subject.dspaceBiology::Immunology
dc.subject.dspaceBiology::Molecular Biology
dc.titleThe immunomodulatory effects of ivermectin on human monocyte-derived dendritic cells
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