Pharmacological Aspect of Indonesian Herbal Medicine in the Treatment of Preeclampsia

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Preeclampsia, a hypertensive disorder of pregnancy, poses significant global health challenges, particularly in developing countries like Indonesia, where it contributes to high maternal and neonatal morbidity and mortality rates. The disorder is marked by hypertension, proteinuria, and multi-organ dysfunction, arising from complex pathophysiological mechanisms including abnormal placentation, immune dysregulation, oxidative stress, and endothelial dysfunction. Conventional treatments focus on managing symptoms and preventing severe complications, but alternative therapies, such as herbal medicine, offer potential complementary approaches, particularly in resource-limited settings. This article explores the therapeutic potential of five herbal medicinal plants—Curcuma longa (turmeric), Apium graveolens (celery), Punica granatum (pomegranate), Glycine max (soybeans), and Cocos nucifera (coconut)—commonly used in Indonesian traditional medicine. These plants possess bioactive compounds with anti- inflammatory, antioxidant, antihypertensive, and anti-cancer properties, which may contribute to the management and prevention of preeclampsia. The integration of these herbal remedies into treatment protocols could optimize preeclampsia management, particularly in settings where conventional pharmaceutical options are limited. However, while these herbs show promise, the article emphasizes the need for further clinical research to validate their efficacy and safety, particularly concerning their bioavailability, potential side effects, and interactions with conventional medications.

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Pharmacology, Preeclampsia, Herbal medicine, Turmaric, Celery, Pomegranate, Soybeans, Coconut
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