[S] Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease

A tétel rövid nézete
dc.contributor.authorAbdul‐Rahman, Toufik
dc.contributor.authorAwuah, Wireko Andrew
dc.contributor.authorMikhailova, Tatiana
dc.contributor.authorKalmanovich, Jacob
dc.contributor.authorMehta, Aashna
dc.contributor.authorNg, Jyi Cheng
dc.contributor.authorCoghlan, Megan Ariel
dc.contributor.authorZivcevska, Marija
dc.contributor.authorTedeschi, Alexander J.
dc.contributor.authorde Oliveira, Emerson Costa
dc.contributor.authorKumar, Akinchita
dc.contributor.authorCantu‐Herrera, Emiliano
dc.contributor.authorLyndin, Mykola
dc.contributor.authorSikora, Kateryna
dc.contributor.authorAlexiou, Athanasios
dc.contributor.authorBilgrami, Anwar L.
dc.contributor.authorAl‐Ghamdi, Khalid Mohammed
dc.contributor.authorPerveen, Asma
dc.contributor.authorPapadakis, Marios
dc.contributor.authorAshraf, Ghulam Md
dc.contributor.authorMehta, Aashna (2025-) (xxx)
dc.contributor.submitterdepDE - ÁOK
dc.date.accessioned2025-01-31T12:53:57Z
dc.date.available2025-01-31T12:53:57Z
dc.date.oa2025-02-03
dc.date.updated2025-01-31T12:53:56Z
dc.description.abstractAlzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological interventions have shown limited efficacy and are associated with significant side effects. Approaches focusing on the early interference with disease pathways, before activation of broad neurotoxic processes, could be promising to slow down symptomatic progression of the disease. Curcumin—an integral component of traditional medicine in numerous cultures worldwide—has garnered interest as a promising AD treatment. Current research indicates that curcumin may exhibit therapeutic potential in neurodegenerative pathologies, attributed to its potent anti-inflammatory and antioxidant properties. Additionally, curcumin and its derivatives have demonstrated an ability to modulate cellular pathways via epigenetic mechanisms. This article aims to raise awareness of the neuroprotective properties of curcuminoids that could provide therapeutic benefits in AD. The paper provides a comprehensive overview of the neuroprotective efficacy of curcumin against signaling pathways that could be involved in AD and summarizes recent evidence of the biological efficiency of curcumins in vivo. © 2024 The Authors. BioFactors published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology.
dc.description.correctorTB
dc.identifier.citationBiofactors. -50 : 4 (2024), p. 693-708. -Biofactors. -0951-6433
dc.identifier.doi10.1002/biof.2039
dc.identifier.issn0951-6433
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM127381
dc.identifier.urihttps://hdl.handle.net/2437/386305
dc.identifier.urlhttps://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.2039
dc.languageeng
dc.rights.accessopen access article
dc.rights.ownerszerző
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.subject.otherAlzheimer's disease
dc.subject.othercurcumin
dc.subject.otherepigenetic regulation
dc.subject.otherneuroinflammation
dc.subject.otheroxidative stress
dc.title[S] Antioxidant, anti‐inflammatory and epigenetic potential of curcumin in Alzheimer's disease
Fájlok
Eredeti köteg (ORIGINAL bundle)
Megjelenítve 1 - 1 (Összesen 1)
Nincs kép
Név:
FILE_UP_0_BioFactors - 2024 - Abdul‐Rahman - Antioxidant anti‐inflammatory and epigenetic potential of curcumin in Alzheimer s.pdf
Méret:
2.93 MB
Formátum:
Adobe Portable Document Format
Leírás:
kiadói változat
Letöltés
Gyűjtemények
Publikációs Adatbázis