Matrix Metalloproteinases In Central Nervous System Diseases

A tétel rövid nézete
dc.contributor.advisorGaál, Botond Ágoston
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Anatómiai, Szövet- és Fejlődéstani Intézethu_HU
dc.contributor.authorCoesfeld, Lucas-Dávid
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDeák, Ádám
dc.contributor.opponentPapp, Tamás
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Sebészeti Intézet::Sebészeti Műtéttani Tanszékhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Radiológiai Klinikahu_HU
dc.date.accessioned2022-08-18T08:44:26Z
dc.date.available2022-08-18T08:44:26Z
dc.date.created2022-08-12
dc.description.abstractMatrix metalloproteinases (MMPs) belong to a unique family of enzymes studied because of their vital role within and outside the central nervous system. By regulating signaling processes and shaping extracellular matrices (ECM), these proteases provide required conditions for many processes both of physiological and pathological nature. Due to their immense destructive power, MMPs require very tight regulation and are only expressed at low levels in healthy individuals, if at all. Regulation is achieved on many levels and is mediated by specific metalloproteinase inhibitors, known as tissue inhibitors of metalloproteinases (TIMPs). Many other factors, molecules, and interactions also play essential roles. To understand the intricate workings of MMPs, we need to understand the ECM, the molecules, the proteins, and the cells that create it. Besides their functions during development, these enzymes have been detected in many pathological conditions. Research has made advances in demonstrating their molecular mechanisms. However, much is still unknown owing to their complexity. Future results will be able to guide specific treatment protocols to cure many diseases in their early phases to prevent future fatal outcomes.hu_HU
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent43hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336574
dc.language.isoenhu_HU
dc.subjectMMPhu_HU
dc.subjectMatrix Metalloproteinaseshu_HU
dc.subjectCNShu_HU
dc.subjectCentral Nervous System Diseaseshu_HU
dc.subjectAnatomyhu_HU
dc.subjectEnzymehu_HU
dc.subjectTIMPhu_HU
dc.subjectTissue Inhibitors Of Metalloproteinaseshu_HU
dc.subjectADAMTShu_HU
dc.subjectADAM with thrombospondin-like motifshu_HU
dc.subjectADAMhu_HU
dc.subjectA-disintegrin and metalloproteasehu_HU
dc.subjectBBBhu_HU
dc.subjectBlood-Brain Barrierhu_HU
dc.subjectSynapsehu_HU
dc.subjectPlasticityhu_HU
dc.subjectAlzheimer's Diseasehu_HU
dc.subjectStrokehu_HU
dc.subjectMalignancyhu_HU
dc.subjectGliomahu_HU
dc.subject.dspaceDEENK Témalista::Orvostudomány::Molekuláris pathológiahu_HU
dc.titleMatrix Metalloproteinases In Central Nervous System Diseaseshu_HU
Fájlok
Gyűjtemények
Theses (Faculty of Medicine)