Investigation of Genetic Polymorphisms Associated with Coronary Heart Diseases in the Hungarian General and Roma Populations

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dc.contributor.advisorFiatal, Szilvia
dc.contributor.advisordeptMegelőző Orvostani Intézet / Department of Preventive Medicinehu_HU
dc.contributor.authorShahbazov, Muslum
dc.contributor.departmentDE--Népegészségügyi Karhu_HU
dc.contributor.opponentZsebik, Barbara
dc.contributor.opponentBárdos, Helga
dc.contributor.opponentdeptDepartment of Biophysics and Cell Biologyhu_HU
dc.contributor.opponentdeptDepartment of Preventive Medicinehu_HU
dc.date.accessioned2016-06-02T09:45:43Z
dc.date.available2016-06-02T09:45:43Z
dc.date.created2016-04-25
dc.description.abstractIn the majority of Central and Eastern European countries, Roma represent over 5% of the population (“by Bernath A. [2009]). Their health status is significantly worse than that if the majority population.The aim of our study was to determine whether a genetic susceptibility does indeed contribute to the higher prevalence of cardiovascular-ill health in the Roma population. This is the first study to investigate several susceptible loci for CHD among Roma living in segregated colonies and to compare them with data for the majority Hungarian population.we examined genetic polymorphisms associated with CHD in four study groups: the Hungarian general population, Hungarian Roma population, clinical controls and clinically submitted cases. We hypothesized that CVD risk calculated on the basis of 22 SNPs is different between study populations.In addition, our study introduced the concept of GRS, a means to aggregate information from multiple gene variants into a single score. This descriptive study assumes that the effect size of SNPs studied was similar in our study populations, than it was found in the populations previously studied and the effect size described. Our results showed that indicators of SC-GRS, OR-GRS and EV-GRS were significantly lower in the HG population. Although a relatively small set of SNPs was selected for inclusion in GRSs, the results imply that it is possible to derive a genetic score that has at least some discriminative ability. The results suggest that genetic susceptibility might underlie the higher prevalence of cardiovascular ill-health in the Roma population.In our study the effect of potential confounders were not considered. However, subsequent analyses are needed because including the major confounding factors (eg.age, BMI, age when disease was diagnosed, blood pressure, sex and HDL, LDL levels) in multivariate logistic regression analyses might further refine the relationship between genetic risk factors and ethnic disparities in CHD prevalence.The obvious limitation of the current study is that the Roma study population was not representative of the overall Roma population in Hungary.hu_HU
dc.description.correctorgj
dc.description.coursenépegészségügyihu_HU
dc.description.courseactnappalihu_HU
dc.description.courselangangolhu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent42hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/228322
dc.language.isoenhu_HU
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectCVDhu_HU
dc.subjectCoronary Heart Diseasehu_HU
dc.subjectSNPhu_HU
dc.subjectGenetic polymorphismhu_HU
dc.subjectCardiovascular diseaseshu_HU
dc.subjectCAD: Coronary Artery Disease/ CHD: Coronary Heart Diseasehu_HU
dc.subjectCHR: Chromosomehu_HU
dc.subjectCS: Coronary Sclerosishu_HU
dc.subjectGenome-wide associated studieshu_HU
dc.subjectHungarian Roma populationhu_HU
dc.subjectIschemic Heart Diseasehu_HU
dc.subjectOdds ratio weighted GRShu_HU
dc.subjectSimple count GRS (SC-GRS)hu_HU
dc.subjectExplained variance weighted GRS (EV-GRS)hu_HU
dc.subjectComparison of genetic risk scoreshu_HU
dc.subjectgenetic basis of CHDhu_HU
dc.subjectJárványtan
dc.subject.dspaceDEENK Témalista::Orvostudomány::Népegészségügyhu_HU
dc.titleInvestigation of Genetic Polymorphisms Associated with Coronary Heart Diseases in the Hungarian General and Roma Populationshu_HU
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