The effects of SGLT2 inhibitor side chain structure on its function and side effects

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by hyperglycemia. The pathophysiology of T2DM is complex but it is known that cells cannot use insulin effectively. The initial treatment for T2DM focuses on a healthy lifestyle, however, if this does not reduce glucose blood levels, oral medication is needed, such as SGLT2 inhibitors. The lack of adherence to the antidiabetic treatment is generally due to the medication's side effects. This increases the rates of complications in diabetic patients. Thus, the main objective of this diploma work is to study how SGLT2 inhibitors' structure may or may not affect smooth muscle intestinal activity and apply this knowledge to avoid its side effects.