Epilepsy, a common neurological condition affecting 50 million people globally, involves recurrent seizures caused by abnormal brain cell firing. It can lead to impaired movement, mood swings, and cognitive abilities. People with epilepsy also suffer from psychological diseases like anxiety and depression. They have a three-fold higher risk of premature death, with rural and low-income regions having the highest rates. Understanding the benefits and drawbacks of Antipsychotic Substances (ASMs) can help reduce negative effects, improve patient quality of life, advance medical care, and be economically beneficial. A study in four countries found an increasing trend of newer ASMs consumption, while older ones declined. The 45 psychiatric adverse drug reactions (ADRs) should also be considered.