These days, it is considered that surgery itself is the only factor that leads to the consequence of the patient’s health improvement or deterioration, but perioperative management. It is essential to consider perioperative factors which lead to an increase in anesthesiologists’ significance in hospitals. Monitoring and management of perioperative to have a successful surgery and to increase mortality, morbidity, and quality of life after surgery. Any chronic pharmacological treatment that affects the function of the cardiovascular, endocrine, or hemostatic systems must be checked in the surgical patients as their health status or condition is different from when they are awake. Drugs may be withdrawn, administered continuously regardless of operations, or only doses are changed. Perioperative drugs that are newly administered include preoperative and postoperative medication. Preoperative agents’ focus is to prepare the surgery to let it be under optimal situation mentally, microbiologically, etc., whereas postoperative agents aim to stabilize the patients after operation for example pain reduction.