Asymmetric synthesis of an AmpC analog boronic acid

A tétel rövid nézete
dc.contributor.advisorFábián, István
dc.contributor.authorKovács, Győző
dc.contributor.departmentDE--TEK--Természettudományi és Technológiai Kar--Kémiai Intézethu_HU
dc.date.accessioned2012-05-15T08:49:30Z
dc.date.available2012-05-15T08:49:30Z
dc.date.created2012-05-14
dc.date.issued2012-05-15T08:49:30Z
dc.description.abstractThe aim of this thesis is to synthetize a boronic acid analog of ampicillin. Ampicillin is a widely emloyed antibiotic in clinical use (for instance, the widely prescribed Augmentin from GlaxoSmithKline) but its use is limited by growing inactivation by β-lactamases, it is desirable necessary to design and synthetise molecules replacing them. Boronic acid bearing structure of ampicillin is likely to be a good ß-lactamase inhibitor. The closer the boronic acid resembles the natural substrate in its interactions with the enzyme, the better its inhibition.hu_HU
dc.description.correctorgj
dc.description.coursevegyészhu_HU
dc.description.degreerégi képzéshu_HU
dc.format.extent51hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/128983
dc.language.isoenhu_HU
dc.rights.accessno_restrictionhu_HU
dc.subjectboronic acidhu_HU
dc.subjectasymmetrichu_HU
dc.subject.dspaceDEENK Témalista::Kémiahu_HU
dc.titleAsymmetric synthesis of an AmpC analog boronic acidhu_HU
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Hallgatói dolgozatok (Természettudományi és Technológiai Kar)