Inflammation is a vital biological response triggered by the immune system in response to various factors like pathogens, cell damage, and toxins. This process can result in acute or chronic inflammation in different organs, potentially causing tissue damage or diseases. Both infectious and non-infectious agents activate inflammatory cells through pathways such as NF- κB, MAPK, and JAK-STAT. While inflammation is a crucial defence mechanism for health, its uncontrolled or chronic state can contribute to various inflammatory diseases. Inflammation is characterized by five macroscopic pathological phenomena, including swelling, elevated tissue temperature, redness of vascularized tissue, intense sensation of noxious stimuli, and impaired function of the affected organ. Chronic inflammation plays a critical role in various diseases, including skin conditions like psoriasis, atopic dermatitis, Seborrheic Dermatitis, Acne Vulgaris and chronic urticaria. The incidence of these disorders, along with their associated comorbidities, is consistently increasing. The pathogenesis of these skin conditions is complex, involving genetic, immunological, and environmental factors. These diseases result from a combination of genetic predisposition, immune dysregulation, hypersensitivity, skin barrier defects, and exposure to environmental triggers. Despite ongoing research, many aspects of their pathogenesis remain poorly understood. In the United States, about 60% of the population suffers from one or more types of chronic inflammatory disorders. In inflammatory conditions, it leads to increased level of pro-inflammatory cytokines and immune cells. This thesis explores the relationship between inflammation and various skin conditions, shedding light on the complexity of immune responses in both acute and chronic settings. The escalating prevalence of chronic inflammatory skin conditions underscores the ongoing need for research and targeted therapeutic strategies. Understanding the molecular foundations and immune responses provides potential avenues for improved interventions. This thesis contributes to the collective knowledge aimed at enhancing the understanding and management of inflammatory skin conditions.