Serum and Salivary Nerve Growth Factor As a Potential Biomarker in Oral Mucositis

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dc.contributor.advisorGebri, Enikő Zsuzsa
dc.contributor.advisordeptFogorvostudományi Kar
dc.contributor.authorHuang, xufeng
dc.contributor.departmentDE--Fogorvostudományi Kar
dc.contributor.opponentdeptFogorvostudományi Kar
dc.date.accessioned2026-06-01T09:13:54Z
dc.date.available2026-06-01T09:13:54Z
dc.date.created2026-02
dc.description.abstractBackground: Nerve growth factor (NGF) plays essential roles in epithelial repair, neuro-immune signalling, and inflammatory pain. However, its dynamic changes during autologous peripheral stem cell transplantation (APSCT) and the relationship to transplant-related mucosal and systemic injury remain poorly understood. The present study aimed to characterize longitudinal alterations in salivary and serum NGF levels during APSCT and to compare them with age-sex matched healthy controls. Materials and Methods: Ten patients with malignant hematological diseases undergoing APSCT were enrolled. Salivary and serum NGF concentrations were measured at four clinically relevant time points: pre-conditioning (Day −3/−7), transplantation day (Day 0), early post-transplant nadir (Day +7), and mucosal recovery phase (Day +14). Healthy controls included volunteers aged 25–34 (n=9), 35–59 (n=7), and ≥60 years (n=7). NGF levels were quantified by ELISA and compared across stages and age groups. Results: Both salivary and serum NGF in APSCT patients showed elevation, with significant increases at Day 0 and a second, more pronounced peak at Day +7, followed by a decline toward recovery by Day +14. This NGF surge paralleled the expected trajectory of conditioning-induced tissue injury and peak post-transplant mucositis. In healthy controls, NGF concentrations in both serum and saliva decreased with age, with the ≥60-year group exhibiting significantly lower baseline levels than younger groups. Conclusions: APSCT induces marked and stage-specific elevations in NGF, likely reflecting acute chemotherapeutic injury, inflammation-driven neuro-immune activation, and subsequent tissue repair responses. The second NGF peak at Day +7 coincides with the nadir phase and the period of greatest mucosal damage, suggesting a potential role for NGF as a biomarker of transplant-related mucosal and systemic stress. Together, these findings highlight NGF as a promising candidate for monitoring tissue injury and recovery in APSCT.
dc.description.coursefogorvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent38
dc.identifier.urihttps://hdl.handle.net/2437/407553
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectAutologous peripheral stem cell transplantation (APSCT), nerve growth factor (NGF), biomarker, oral mucositis
dc.subject.dspaceMedicine
dc.titleSerum and Salivary Nerve Growth Factor As a Potential Biomarker in Oral Mucositis
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