Atopic dermatitis is a chronic inflammatory skin condition affecting many globally, marked by itching, redness, dryness, and eczematous lesions. Its development is intricate, involving genetics, environment, and immune factors. It's associated with conditions like asthma and allergic rhinitis. Traditionally, treatment involves managing symptoms with topical corticosteroids, systemic corticosteroids, and immunomodulatory agents like cyclosporine and azathioprine. These approaches can have drawbacks and are not universally effective. Recent advancements, however, have led to new therapies including biologics and JAK inhibitors. These target specific inflammatory pathways, showing efficacy in moderate-to-severe atopic dermatitis by reducing symptoms, lessening topical corticosteroid reliance, and enhancing quality of life.