Pharmacotherapy of Trigeminal neuralgia

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dc.contributor.advisorSzentmiklósi, József András
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.authorNwoguwgwu, Ezinne Uche
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentPórszász, Róbert
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék
dc.date.accessioned2023-04-13T10:08:37Z
dc.date.available2023-04-13T10:08:37Z
dc.date.created2023-03-17
dc.description.abstractTrigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by recurrent paroxysmal electric shock-like or stabbing pain within the distribution of one or more divisions of the trigeminal nerve. The pain typically lasts for a few seconds to two minutes however, some patients experience concomitant continuous pain. Pain paroxysms can be triggered by innocuous stimuli such as talking, eating, brushing teeth, shaving, a light touch, or a cool breeze. The pain paroxysm can also occur spontaneously. The most common theory for the aetiology of TN is neurovascular compression at the root entry zone which leads to demyelination of primary sensory trigeminal afferent fibers. Multiple sclerosis or a space-occupying lesion affecting the trigeminal nerve can cause secondary trigeminal neuralgia. The diagnosis of TN is primarily based on a detailed clinical history that fits the accepted diagnostic criteria although imaging studies can be used for differential diagnosis. Carbamazepine or its keto derivative, oxcarbazepine is the first choice in the treatment for TN. Other anticonvulsants such as lamotrigine and gabapentin and other drugs can be used. Neurosurgical treatments may benefit patients for whom medical therapy has been ineffective or has been poorly tolerated.
dc.description.correctorLB
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent39
dc.identifier.urihttps://hdl.handle.net/2437/349353
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjecttrigeminal neuralgia
dc.subjectpain
dc.subjecttrigeminal neuralgia
dc.subjectanticonvulsants
dc.subjectmicrovascular decompression
dc.subject.dspaceDEENK Témalista::Orvostudomány
dc.titlePharmacotherapy of Trigeminal neuralgia
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