Pharmacological intervention of COVID-19 induced cytokine storm

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorYang, EunBi Ashley
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentdeptKenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2022-08-29T09:32:59Z
dc.date.available2022-08-29T09:32:59Z
dc.date.created2022-03-11
dc.description.abstractCOVID-19 infection can cause heterogenous course of disease; from mild asymptomatic upper respiratory infection to life threatening hyperinflammatory state, so called cytokine storm. The COVID-19 cytokine storm progressively deteriorates patients into states of acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF) with high mortality rate. Based on the amount of cytokine, cytokine storm is divided into mild drizzle of cytokines, severe cytokine storm, and critical hurricane CRS, and each phase differ in severity and mortality.Particularly, pro-inflammatory cytokines (e.g IL-6, Il-2, TNF-α, IFN-γ) and lymphopenia are noticeable in patients with COVID-19. Several cohort studies have shown that some cytokine inhibitors such as tocilizumab or baricitinib improved the clinical outcomes in COVID-19 patients. Potent pharmacological interventions, such as glucocorticoids, anti-malarial agents, cytokine monoclonal antibodies, and chemokine inhibitors have been studied in COVID-19 patients as well. This thesis presents general pharmacokinetics, rationale mechanism for COVID-19, indications, current case study result, and adverse effects of each drug.hu_HU
dc.description.correctorhbk
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent35hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336873
dc.language.isoenhu_HU
dc.subjectCovid-19hu_HU
dc.subjectcytokine stormhu_HU
dc.subjectimmunomodulatory drugshu_HU
dc.subjecthyper inflammatory stateshu_HU
dc.subjectARDShu_HU
dc.subjectMOFhu_HU
dc.subjectpro-inflammatory cytokineshu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titlePharmacological intervention of COVID-19 induced cytokine stormhu_HU
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Theses (Faculty of Medicine)