The therapeutic indications for SSRIs, adverse effect profiles, variations among classes, and possible associations with SI were all covered in this study. SSRIs were first used to treat depressive disorders, such as unipolar depression, but they are now also used to treat anxiety disorders, other mental illnesses, and a few physical ailments. Depending on the comorbidities, genetics, and probable side effects of the patient, each SSRI has distinct qualities which render it a better match for certain persons. Patients who require multiple pharmacologic treatments for various conditions may benefit from considering an SSRI like citalopram or escitalopram that does not inhibit cytochrome P450 enzymes, as this can help prevent potential drug-drug interactions. Although SSRIs are far more well tolerated than MAOIs and TCAs that came before them, there are still some possible side effects. A few of the most typical ones include sexual dysfunction, GI discomfort, sleeplessness, and irritability. The black box warning for a higher probability of SI in children and young people aged 18 to 24 is one of the most contentious side effects of SSRIs. The intricacies and interactions of SSRIs in a depressed young person's growing brain are poorly understood. Adults without particular risk characteristics, as previously mentioned, do not seem to be at elevated risk of suicidality. In the end, a risk-benefit analysis must take the possible effects of the condition to be treated, side effects, and risks into account before prescribing SSRIs to any patient.