This study looks at two synthetic compounds made from Cannabis sativa, named PFD-11A and PFD-35/II, and how they affect skin cancer cells called melanoma. These cancer cells are usually hard to treat, so new drug options are needed. The researchers tested the compounds on two different melanoma cell lines and found that PFD-35/II was more effective at killing the cells. The drugs reduced the cancer cells’ ability to grow and survive over time. They also seemed to work by triggering processes like autophagy and cell death. The findings suggest these compounds could be useful for treating melanoma, but more research, especially in animals, is needed to confirm this.