Contemporary evaluation and treatment of medulloblastoma

A tétel rövid nézete
dc.contributor.advisorKiss, Csongor
dc.contributor.advisordeptDepartment of Pediatricshu_HU
dc.contributor.authorKyo, Ito
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentNovák, László
dc.contributor.opponentGáspár, Imre
dc.contributor.opponentdeptDepartment of Neurosurgeryhu_HU
dc.contributor.opponentdeptDepartment of Pediatricshu_HU
dc.date.accessioned2018-09-26T10:06:10Z
dc.date.available2018-09-26T10:06:10Z
dc.date.created2018-04-18
dc.description.abstractMedulloblastoma is the most common malignant brain tumor affecting the pediatric population. Expansion of knowledge on biological profiles over the last decade identified four distinct molecular subgroups, including WNT, SHH, and non-WNT/non-SHH (Group 3 and 4), and triggered substantial changes in evaluation and treatment of medulloblastoma. Molecular information is now an essential part of diagnosis and risk stratification. Current standard of care consists of combinations of surgery, radiotherapy, and chemotherapy, however, development of treatments specific to each subgroup is an ongoing approach to improve the outcome furthermore. The focus of this thesis is to summarize the modern updates in classification, diagnosis, and treatment of medulloblastoma driven by discoveries of molecular heterogeneity.hu_HU
dc.description.correctorhbk
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent19hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/257251
dc.language.isoenhu_HU
dc.subjectMedulloblastomahu_HU
dc.subjectclassification
dc.subjecttreatment
dc.subject.dspacePediatricshu_HU
dc.titleContemporary evaluation and treatment of medulloblastomahu_HU
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