The Endocannabinoid System: Overview, Therapeutic Applications and Future Perspectives

A tétel rövid nézete
dc.contributor.advisorTósaki, Árpád
dc.contributor.advisordeptDebreceni Egyetem::Gyógyszerésztudományi Karhu_HU
dc.contributor.advisordeptDepartment of Pharmacodynamicshu_HU
dc.contributor.authorTalab, Abdullah Abdulrahman
dc.contributor.departmentDE--Gyógyszerésztudományi Karhu_HU
dc.contributor.opponentFenyvesi, Ferenc
dc.contributor.opponentSzabó, Zsuzsanna
dc.contributor.opponentdeptDebreceni Egyetem::Gyógyszerésztudományi Karhu_HU
dc.contributor.opponentdeptDepartment of Pharmaceutical Technologyhu_HU
dc.contributor.opponentdeptDepartment of Biopharmacyhu_HU
dc.date.accessioned2021-05-28T12:38:55Z
dc.date.available2021-05-28T12:38:55Z
dc.date.created2021-04-21
dc.description.abstractThe endocannabinoid system is an incredibly pervasive network, influencing the homeostasis of immune, cardiovascular, central nervous, and cutaneous systems, among many others. The biological effects of the endocannabinoid system were gleaned mostly from the natural source, the plant Cannabis sativa, native to Central Asia and the Indian subcontinent. The plant has been mostly exploited for its euphoriant and relaxant properties, however, the endocannabinoid system is slowly entering the forefront of pharmacotherapy of various clinical entities. The recent isolation of the functional endocannabinoid receptor led to the appreciation of the scope of intracellular signalling and the far-reaching genomic and non-genomic consequences of the cannabinoid receptor activation. This thesis aims to provide a well-rounded overview of the physiology of the endocannabinoid system, its role in the homeostasis of many functional systems in the body, a description of various potentially therapeutic ligands at the cannabinoid receptors, and the numerous opportunities which provide a glimpse into new avenues in drug discovery and development. The industry has attempted to devise novel therapeutic approaches to the endocannabinoid system in the past, however, successful molecules are rare and restricted to only a few clinical indications. The thesis will discuss the possible foci of application of new endocannabinoid targets and the clinical relevance of new, promising therapies.hu_HU
dc.description.coursegyógyszerészhu_HU
dc.description.courselangangolhu_HU
dc.description.coursespecOrvosbiológia-farmakológiahu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent37hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/310447
dc.language.isoenhu_HU
dc.subjectendocannabinoidhu_HU
dc.subjectTHChu_HU
dc.subjectCBDhu_HU
dc.subjectanandamidehu_HU
dc.subjectFAAHhu_HU
dc.subjectPPARhu_HU
dc.subject2-arachidonoylglycerolhu_HU
dc.subjectMAGLhu_HU
dc.subjectCB1 receptorhu_HU
dc.subjectCB2 receptorhu_HU
dc.subjectaddictionhu_HU
dc.subjectinflammationhu_HU
dc.subjectneurodegenerationhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleThe Endocannabinoid System: Overview, Therapeutic Applications and Future Perspectiveshu_HU
Fájlok
Gyűjtemények
Theses (Faculty of Pharmacy)