MDMA-assisted psychotherapy for the treatment of PTSD

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorMazor, David
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentDrimba, László
dc.contributor.opponentMegyeri, Attila
dc.contributor.opponentdeptKenézy Kórház, Központi Aneszteziológiai és Intezív Terápiás Osztályhu_HU
dc.contributor.opponentdeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.date.accessioned2022-08-15T10:09:35Z
dc.date.available2022-08-15T10:09:35Z
dc.date.created2022-03-04
dc.description.abstractRecent evidence suggests that MDMA-assisted Psychotherapy for the treatment of PTSD might help treatment-resistant patients. Treatment-resistant post-traumatic stress disorder patients do not have many therapeutic options since the currently used medications are of limited help. MDMA is an empathogen-entactogen drug that affects various processes of fear extinction, emotional processing, and memory reconsolidation. In the first phase-3 RCT by Mitchell et al. the MDMA-assisted therapy group showed a greater CAPS-5 score reduction (-24.4) compared to the placebo group (-13.9) after three sessions. MDMA was found to be safe, well-tolerated and with high efficacy in the treatment of severe PTSD, as well as the dissociative type of PTSD, compared to placebo. At the end point of the primary phase-3 study 67% of the participants in the MDMA group compared to 32% of the participants in the placebo group no longer met the diagnostic criteria for PTSD. MDMA-Assisted Psychotherapy is a potential candidate for being a first-line treatment for PTSD, upon approval from the FDA, with greater efficacy, length of remission, safety, and side effect profile compared to placebo.hu_HU
dc.description.correctorhbk
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent39hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/336461
dc.language.isoenhu_HU
dc.subject3,4-methylenedioxymethamphetamine (MDMA)hu_HU
dc.subjectPost-traumatic Stress Disorderhu_HU
dc.subjectPsychotherapyhu_HU
dc.subjectTreatment-resistant PTSDhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleMDMA-assisted psychotherapy for the treatment of PTSDhu_HU
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