Chemotherapeutic Treatment of Advanced Cervical Cancer

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dc.contributor.advisorPórszász, Róbert
dc.contributor.advisordeptDebreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézethu_HU
dc.contributor.authorCayasso, Mayella Roberta
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentSzentmiklósi, József András
dc.contributor.opponentDrimba, László
dc.contributor.opponentdeptUniversity of Debrecen::Faculty of Pharmacyhu_HU
dc.contributor.opponentdeptKenézy Kórház, Aneszteziológiai tanszékhu_HU
dc.date.accessioned2014-06-23T14:35:31Z
dc.date.available2014-06-23T14:35:31Z
dc.date.created2014-03-14
dc.date.issued2014-06-23T14:35:31Z
dc.description.abstractIn this day and age, management of advanced, recurrent or persistent cervical cancer includes radiotherapy and chemotherapy. Radiation has been the primary treatment modality for locoregionally advanced cervical cancer. Accompanying systemic cisplatin chemotherapy and radiation have shown high response rates with improvements in long-lasting remissions and overall survival. In this review, we see that cisplatin has been the standard medication for the treatment of advanced cervical cancer, as early as 1985.The top 3 combination treatments were: cisplatin and paclotaxel, followed by cisplatin and gemcibine and topotecan and cisplatin. These achieved increased response and overall survival rates (10.25-12.87 months) and a progression free survival ranging from 4.57- 5.82 months, without further compromising the patients’ quality of life. This review focuses on the mechanism of action and toxicities of the above mentioned drugs, as well as their role as a chemotherapeutic agent in the management of advanced, recurrent, or persistent cervical cancer. Other combination modalities and dosages are also discussed.hu_HU
dc.description.correctorVÁ
dc.description.courseáltalános orvoshu_HU
dc.description.courselangangolhu_HU
dc.description.degreeegységes, osztatlanhu_HU
dc.format.extent43hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/194764
dc.language.isoenhu_HU
dc.rights.accessno_restrictionhu_HU
dc.subjectChemotherapyhu_HU
dc.subjectCisplatinhu_HU
dc.subjectCervicalhu_HU
dc.subjectCancerhu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titleChemotherapeutic Treatment of Advanced Cervical Cancerhu_HU
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Theses (Faculty of Medicine)