This dissertation addressed the concept and development of a cost-effective mechatronics rehabilitation device with a hybrid mechanism by adopting the combination of grounded-exoskeleton and end-effector mechanism. The proposed system targeted the four fingers plus the thumb and the wrist for either right or left hands. It was aimed to step forward to improve the related existing devices. The objective of the proposed system is to help the users regain both right and/or left-hand functionality and sensory-motor and reduce spasticity, muscle tone on the hand, and observe and evaluate their recovery steps. It was designed The intended system is designed to be a single device that capable of performing to aid the survivors who suffer hemiparesis of the upper arm caused by brain injury, spinal cord injury, tendon shatters, or fall-related injuries to perform four crucial movements: fingers F/E including the thumb F/E , wrist F/E, wrist E/U, and hand forearm S/P. Unlike the related work in the literature, the proposed system’s with a single design could train the mentioned joints. Additionally, the overall structure does not load the hand with a heavy and complex mechanical structure and efficiently trains the targeted joints. Additionally, owning an interactive embedded dashboard equipped with time-based self-assessment implementations enables the therapist to set then train, then evaluate the therapy control parameters conveniently. Moreover, the proposed system is equipped with specially developed game-based therapy which enabled the users to actively moves their wrist. Besides, the proposed system was validated and tested with repeatable experimental tests to evaluate and validate the device's functionality. The results of the tests indicate that the proposed system performed and met the requirements of an active, passive plus continuous passive motion, and interactive training modes configurations, and according to the set control parameters and the planned range of motions with minor and negligent errors.