Inflammation is a common protective mechanism to remove initial cause of cell injury. In the nervous system, sensory nerves and leukocytes regulate inflammation by secretion of neuropeptides such as substance P and neurokinin A centrally and peripherally causing neurogenic inflammation. It causes several diseases in different organs: migraines, asthma, atopic dermatitis, and psoriasis. The pharmacology effect of neurogenic inflammation depends on the receptors located in the organs. A variety of drugs have now been developed and are effective against neurogenic inflammation.