For decades, malaria has been known to be a lethal disease which can be transmitted quickly via the mosquito vector and cause outbreaks in many areas in the world. The symptoms and signs of malaria are very non-specific, with paroxysm fever and headache are the most common ones, which can be even absent in some cases. Therefore, its diagnosis is highly based on laboratory findings as well as a history of recent travels to any endemic regions. In addition, due to a lack of an officially approved vaccination, the physician’s early and right diagnosis with a good treatment plan are extremely important in case of malaria infection. Malaria is varied according to the stages of infection including erythrocytic and exo-erythrocytic stages, or it can be classified based on the different parasite’s strains, which all have distinct pharmacology treatments. Chloroquine has been the most commonly used drugs for a long time and artemisinin and its derivatives are the new antimalarial agents that have been recently proved by a Chinese scientist in 2015.