As professionals work longer hours and live longer, there have been concerns about work-related musculoskeletal disorders (WMSDs) affecting both work and personal life. The goal of this study was to look at the prevalence and risk factors of WMSD among Syrian practicing dentists and to examine stress levels among them. Also, it was to assess their awareness of their working conditions and the physical activity they typically engage in. The study questionnaire was created based on the Nordic Standardized Questionnaire and the Perceived Stress Scale. 179 Syrian practicing dentists took a part in this study, (69.6%) male, and (37.4%) female. The majority of the sample had only a bachelor's degree in dentistry (73.7%). We discovered that they have a high prevalence of WMSDS, which was (87.7%). The most affected areas were the neck (81.1%), lower back (79.1%), and shoulders (64.9%) during the last 12 months and also during the last seven days. These proportions agree with the other studies and all of them showed the affected areas in the same order. (66.5%) were bothered by WMSDS pain in their daily lives and normal activities, and (66.5%) were taking medications to alleviate it. In this study, the sample years of experience ranged between (1-30) years and was on average (5 years). And they work on average for (21) hours per week, and it ranged between (2-90) hours weekly, and they see an atypical number of patients, which is 8 patients per day. As is known about dentistry, it is one of the most stressful occupations. Stress can cause muscle contraction and pain, and (86 percent) of the sample size in this study is under extreme stress. Practicing physical activity exercises and stretching is very important to reduce muscle damage. In this study, only (24%) of the participants practiced regular exercises. There is a need for dental students to be made aware of potential musculoskeletal problems at an early stage. Physical activities like yoga and stretching exercises should be done regularly. An educational program in ergonomics should be added to the university's schedule. Dentists are exposed to a wide range of occupational risks in their profession that are unique to this profession.