[S] A complete nicotinate degradation pathway in the microbial eukaryote Aspergillus nidulans

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dc.contributor.authorBokor, Eszter
dc.contributor.authorÁmon, Judit
dc.contributor.authorVarga, Mónika
dc.contributor.authorSzekeres, András
dc.contributor.authorHegedűs, Zsófia
dc.contributor.authorJakusch, Tamás
dc.contributor.authorSzakonyi, Zsolt
dc.contributor.authorFlipphi, Michel
dc.contributor.authorVágvölgyi, Csaba
dc.contributor.authorGácser, Attila
dc.contributor.authorScazzocchio, Claudio
dc.contributor.authorHamari, Zsuzsanna
dc.contributor.authorMichel Flipphi (2024-) (xxx)
dc.contributor.submitterdepBiotechnológiai Intézet -- 4401
dc.contributor.submitterdepBiomérnöki Tanszék -- 755
dc.contributor.submitterdepTTK
dc.contributor.submitterdepDebreceni Egyetem
dc.date.accessioned2024-03-28T11:05:52Z
dc.date.available2024-03-28T11:05:52Z
dc.date.oa2024-04-02
dc.date.updated2024-03-28T11:05:52Z
dc.description.abstractSeveral strikingly different aerobic and anaerobic pathways of nicotinate breakdown are extant in bacteria. Here, through reverse genetics and analytical techniques we elucidated in Aspergillus nidulans, a complete eukaryotic nicotinate utilization pathway. The pathway extant in this fungus and other ascomycetes, is quite different from bacterial ones. All intermediate metabolites were identified. The cognate proteins, encoded by eleven genes (hxn) mapping in three clusters are co-regulated by a specific transcription factor. Several enzymatic steps have no prokaryotic equivalent and two metabolites, 3-hydroxypiperidine-2,6-dione and 5,6-dihydroxypiperidine-2-one, have not been identified previously in any organism, the latter being a novel chemical compound. Hydrolytic ring opening results in α-hydroxyglutaramate, a compound not detected in analogous prokaryotic pathways. Our earlier phylogenetic analysis of Hxn proteins together with this complete biochemical pathway illustrates convergent evolution of catabolic pathways between fungi and bacteria.
dc.description.correctorTCS
dc.identifier.citationCommunications Biology. -5 : 1 (2022), p. 1-11. -Commun. Biol. -2399-3642
dc.identifier.doi10.1038/s42003-022-03684-3
dc.identifier.issn2399-3642
dc.identifier.opachttps://ebib.lib.unideb.hu/ebib/CorvinaWeb?action=cclfind&resultview=long&ccltext=idno+BIBFORM119928
dc.identifier.urihttps://hdl.handle.net/2437/368017
dc.identifier.urlhttps://www.nature.com/articles/s42003-022-03684-3
dc.languageeng
dc.rights.accessopen acces article
dc.rights.ownerszerző
dc.subject.otheridegen nyelvű folyóiratközlemény külföldi lapban
dc.subject.otherAspergillus nidulans
dc.subject.otherEukaryota
dc.subject.otherNiacin
dc.subject.otherPhylogeny
dc.subject.otherTranscription Factors
dc.subject.othernicotinic acid
dc.subject.othertranscription factor
dc.subject.othereukaryote
dc.subject.othergenetics
dc.subject.othermetabolism
dc.subject.otherphylogeny
dc.title[S] A complete nicotinate degradation pathway in the microbial eukaryote Aspergillus nidulans
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