Astrocyte Overstimulation of the Pedunculopontine Nucleus Influences Movement, Activity Cycles, and Learning

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dc.contributor.advisorPál, Balázs
dc.contributor.advisorBaneen, Maamrah
dc.contributor.advisordeptÁltalános Orvostudományi Kar::Élettani Intézet
dc.contributor.authorAbdal-Hadi, Ali
dc.contributor.departmentDE--Általános Orvostudományi Kar
dc.contributor.opponentTibor
dc.contributor.opponentdeptÁltalános Orvostudományi Kar
dc.date.accessioned2025-05-20T11:52:56Z
dc.date.available2025-05-20T11:52:56Z
dc.date.created2025-05-20
dc.description.abstractAstrocytes maintain and stabilize PPN neural function, with a variety of mechanisms, whilst also having the potential to directly influence neuronal function through neuromodulatory receptors and calcium waves. These effects are heterogeneous in nature, based on the background of the neural network in which the astrocytes reside. This is in confirmation with the supportive role that astrocytes are known to have based on astrocyte-neural relationships, but unlike in cortical regions where astrocytes have certain synchronizing roles, they are less pronounced in the brainstem. Still, they have many of the similar mechanisms of influence such as SICs and tonic currents. These mechanisms are very likely involved in the varied functions of the PPN including wakefulness, sensory gating, reward, locomotion, attention and associated learning and active memory. Perhaps the understanding of the in vivo significance of astrocyte overstimulation can be compared to the known pathogenesis and clinical features of diseases such as Parkinson’s and more specifically Progressive Supranuclear Palsy (PSP). Our conducted experiment can help prove that our DREADD modified mice can act as models of PSP and consequently models for pharmacological testing in PSP management and treatment.
dc.description.courseáltalános orvos
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent43
dc.identifier.urihttps://hdl.handle.net/2437/390169
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectAstrocytes
dc.subjectPedunculopontine Nucleus
dc.subjectNeuromodulation
dc.subjectDREADD
dc.subjectMice
dc.subjectBehavioral test
dc.subject.dspaceMedicine::Life Science
dc.subject.dspaceBiology::Neurobiology
dc.subject.dspaceBiology::Cell Physiology
dc.titleAstrocyte Overstimulation of the Pedunculopontine Nucleus Influences Movement, Activity Cycles, and Learning
dc.title.subtitleInvestigation of in-vivo effects of astrocyte overstimulation in the PPN using DREADDs and behavioral tests in mice
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