The role of calcium channel blockers in the modern antihypertenive therapy
dc.contributor.advisor | Pórszász, Róbert | |
dc.contributor.advisordept | Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | |
dc.contributor.author | Alkhlaifat, Mohammad Aqel Mohammad | |
dc.contributor.department | DE--Általános Orvostudományi Kar | |
dc.contributor.opponent | Drimba, László | |
dc.contributor.opponent | Szentmiklósi, József András | |
dc.contributor.opponentdept | Debreceni Egyetem::Általános Orvostudományi Kar::Aneszteziológiai és Intenzív Terápiás Tanszék | |
dc.contributor.opponentdept | Debreceni Egyetem::Általános Orvostudományi Kar::Farmakológiai és Farmakoterápiai Intézet | |
dc.date.accessioned | 2023-05-03T08:24:34Z | |
dc.date.available | 2023-05-03T08:24:34Z | |
dc.date.created | 2022-06-24 | |
dc.description.abstract | L-type CCBs have been routinely employed in the treatment of arterial hypertension for over 40 years.In recent years, Western countries have ceased the development of new L-type CCBs with great vascular selectivity and long-lasting antihypertensive effects, while Japan has created novel CCBs that block not only L-type, but also L-/T, T-/N, or L-/T-/N-type Ca 2+ channels. These novel CCBs have antihypertensive effects that are similar to those of traditional L-type CCBs. They do, however, dilate both afferent and efferent arterioles, lowering filtration fraction and glomerular hypertension, decreasing proteinuria, and maybe slowing the progression of kidney disease to a greater extent than L-type CCBs. Furthermore, dual L/T and T/N-type CCBs cause minimal or no reflex tachycardia, reduce aldosterone secretion, and cause less pretibial edema. | |
dc.description.corrector | LB | |
dc.description.course | általános orvos | |
dc.description.courselang | angol | |
dc.description.degree | egységes, osztatlan | |
dc.format.extent | 39 | |
dc.identifier.uri | https://hdl.handle.net/2437/351550 | |
dc.language.iso | en | |
dc.rights.access | Hozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében. | |
dc.subject | epidemiology and causes of hypertension | |
dc.subject | treatment of hypertension | |
dc.subject | calcium channel blocker | |
dc.subject.dspace | DEENK Témalista::Orvostudomány::Farmakológia | |
dc.title | The role of calcium channel blockers in the modern antihypertenive therapy |