The effect of deoxycholic acid, a bacterial metabolite, on intestinal motility.

Abstract

This study examined the effects of deoxycholic acid (DCA) on mouse ileal contractility. An organ bath system recorded motor responses to DCA at 100, 500, and 1000 nM. DCA was tested under both basal conditions and carbachol-induced hyperactivity. Results show DCA selectively inhibits carbachol activity while preserving the spontaneous contractility. DCA acts as a "physiological buffer" to stabilize intestinal movement during over-stimulation. These findings support targeting bile acid pathways to treat motility disorders like IBS and IBD.