The effect of deoxycholic acid, a bacterial metabolite, on intestinal motility.

dc.contributor.advisorUray, Karen Lee
dc.contributor.authorJafo, Rima
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biológiai és Ökológiai Intézet
dc.date.accessioned2026-06-08T11:14:24Z
dc.date.available2026-06-08T11:14:24Z
dc.date.created2026-04-11
dc.description.abstract1. This study examined the effects of deoxycholic acid (DCA) on mouse ileal contractility. 2. An organ bath system recorded motor responses to DCA at 100, 500, and 1000 nM. 3. DCA was tested under both basal conditions and carbachol-induced hyperactivity. 4. Results show DCA selectively inhibits carbachol activity while preserving the spontaneous contractility. 5. DCA acts as a "physiological buffer" to stabilize intestinal movement during over-stimulation. 6. These findings support targeting bile acid pathways to treat motility disorders like IBS and IBD.
dc.description.courseBiology
dc.description.degreeMSc/MA
dc.format.extent32
dc.identifier.urihttps://hdl.handle.net/2437/408050
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectGut Microbiota
dc.subjectDeoxycholic Acid
dc.subjectSecondary Bile Acids
dc.subjectIntestinal Motility
dc.subjectIleum
dc.subjectOrgan Bath
dc.subject.dspaceChemistry
dc.titleThe effect of deoxycholic acid, a bacterial metabolite, on intestinal motility.
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