Phsiological rules of the multidrug resistance transporter P-glcoprotein

A tétel rövid nézete
dc.contributor.advisorBacsó, Zsolt
dc.contributor.advisordeptDepartment of Biophysics and Cell Biologyhu_HU
dc.contributor.authorFaraj, Nabeel
dc.contributor.departmentDE--Általános Orvostudományi Karhu_HU
dc.contributor.opponentUray, Karen Lee
dc.contributor.opponentdeptÁltalános Orvostudományi Kar :: Orvosi Vegytani Intézethu_HU
dc.date.accessioned2022-06-01T16:06:24Z
dc.date.available2022-06-01T16:06:24Z
dc.date.created2022-04-26
dc.description.abstractThe thesis introduction talk about ABC transporters and their structures, P-glycoprotein and its mechanism of action, Cancer multidrug resistance, substrates, and inhibitors, The physiological role of Pgp, its expression and function in the immune cell populations, and its impact on the immune cells in cancer.In this work, our primary focus was on the evaluation of the Physiological expression of Pgp in human T lymphocytes, particularly in the primary human cytotoxic T lymphocytes (CTLs), besides its expression in two other lymphoid origin human tumor cell lines derived from hematological malignancies of the CD4+ Jurkat and the CD8+ TALL-1.Cells used were Primary human cytotoxic T lymphocytes, Jurkat, TALL-1, NIH 3T3 cells and NIH 3T3 MDR1 cells. Fluorescence microscopy and Flow cytometry were used to assay the calcein accumolation inside these cells with and without cyclosporin A.hu_HU
dc.description.coursemolekuláris biológiahu_HU
dc.description.courselangangolhu_HU
dc.description.coursespecImmunológia, sejt- és mikrobiológiahu_HU
dc.description.degreeMSc/MAhu_HU
dc.format.extent45hu_HU
dc.identifier.urihttp://hdl.handle.net/2437/334219
dc.language.isoenhu_HU
dc.subjectP-glycoproteinhu_HU
dc.subjectmultidrug resistancehu_HU
dc.subjectABC transportershu_HU
dc.subjectThe physiological role of P-gphu_HU
dc.subject.dspaceDEENK Témalista::Orvostudományhu_HU
dc.titlePhsiological rules of the multidrug resistance transporter P-glcoproteinhu_HU
Fájlok
Gyűjtemények
Theses (Faculty of Medicine)