I conducted experimental research on the mechanism of CLGBI inhibition of NaV1.4 channels. I overlooked the structure, expression, and physiology of the sodium channels. Additionally, I investigated potential toxins that could be used in clinical studies as blockers of sodium current. During the experimental research, I used the patch clamp technique to record current and analyzed the results using computer software. The obtained results showed evidence supporting previous studies, indicating that CLGBI is a non-selective blocker, as it only partially blocks sodium channels and demonstrates similar results for a wide range of voltage-gated channels. In conclusion, CLGBI could be considered as a potential blocker; however, for better selectivity for specific voltage-gated channels, other inhibitors should be examined.