Study of the mechanism of ClGBI inhibition of NaV1.4 channels

A tétel rövid nézete
dc.contributor.advisorSzanto , Gábor Tibor
dc.contributor.authorZaikina, Yulia
dc.contributor.departmentDE--Természettudományi és Technológiai Kar--Biotechnológiai Intézet
dc.date.accessioned2023-12-12T14:20:41Z
dc.date.available2023-12-12T14:20:41Z
dc.date.created2023-11-17
dc.description.abstractI conducted experimental research on the mechanism of CLGBI inhibition of NaV1.4 channels. I overlooked the structure, expression, and physiology of the sodium channels. Additionally, I investigated potential toxins that could be used in clinical studies as blockers of sodium current. During the experimental research, I used the patch clamp technique to record current and analyzed the results using computer software. The obtained results showed evidence supporting previous studies, indicating that CLGBI is a non-selective blocker, as it only partially blocks sodium channels and demonstrates similar results for a wide range of voltage-gated channels. In conclusion, CLGBI could be considered as a potential blocker; however, for better selectivity for specific voltage-gated channels, other inhibitors should be examined.
dc.description.courseBiochemical Engineering
dc.description.degreeBSc/BA
dc.format.extent22
dc.identifier.urihttps://hdl.handle.net/2437/362196
dc.language.isoen
dc.rights.accessHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectCLGBI, NaV1.4, inhibition
dc.subject.dspaceDEENK Témalista::Biológiai tudományok
dc.titleStudy of the mechanism of ClGBI inhibition of NaV1.4 channels
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