Formulation and evaluation of a tipical preparation containing Roflumilast

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dc.contributor.advisorPető, Ágota
dc.contributor.advisordeptGyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék
dc.contributor.authorMahdavi, Mahyar
dc.contributor.departmentDE--Gyógyszerésztudományi Kar
dc.contributor.opponentBácskay, Ildikó
dc.contributor.opponentBak, Istvan
dc.contributor.opponentdeptGyógyszerésztudományi Kar::Gyógyszertechnológiai Tanszék
dc.contributor.opponentdeptGyógyszerésztudományi Kar::Gyógyszerhatástani Tanszék
dc.date.accessioned2026-04-14T12:31:11Z
dc.date.available2026-04-14T12:31:11Z
dc.date.created2026-02-27
dc.description.abstractPsoriasis is a chronic, proliferative, inflammatory dermatologic disease that accelerates the skin cell proliferation rate from 26-28 days to 3-4 days, resulting in increased skin thickness and cutaneous plaques. Its symptoms are red lesions with white scales and silver colored flakes, accompanied by a burning sensation and pruritus. The most common type of psoriasis is Plaque Psoriasis; topical agents are also the best therapeutic approach in the case of Mild-to-Moderate Plaque Psoriasis. Roflumilast is a selective phosphodiesterase-4 (PDE-4) inhibitor that was approved as a topical agent in the case of mild-to-moderate plaque psoriasis by the U.S. Food and Drug Administration (FDA). Its mechanism of action in this skin disease is not yet fully understood, but it likely provides anti-inflammatory effects. This paper aimed to formulate and evaluate a nanogel containing Roflumilast. Two gel compositions were prepared with and without hydroxypropyl-beta-cyclodextrin (HPBCD). Physicochemical characterization included pH measurement, rheological analysis, particle size analysis, and in vitro drug-release studies. Both nanogels showed acceptable values in the case of pH measurements. Rheology analysis confirmed shear-thinning behavior, which is favorable for topical preparations. Particle size analysis demonstrated smaller values for the nanogel containing Roflumilast and HPBCD compared to the nanogel containing Roflumilast. An in-vitro drug release study indicated higher drug release in the case of the nanogel containing Roflumilast and HPBCD. In conclusion, Roflumilast nanogels were successfully formulated and showed suitable physicochemical properties for topical use. The incorporation of HPBCD increased the solubility of Roflumilast in Tween 80, reduced particle size, and enhanced drug release.
dc.description.coursegyógyszerész
dc.description.courselangangol
dc.description.degreeegységes, osztatlan
dc.format.extent40
dc.identifier.urihttps://hdl.handle.net/2437/406226
dc.language.isoen
dc.rights.infoHozzáférhető a 2022 decemberi felsőoktatási törvénymódosítás értelmében.
dc.subjectRoflumilast
dc.subjectNanogel
dc.subjectNanogel preparation
dc.subjectPlaque psoriasis
dc.subjectHydroxypropyl-beta-cyclodextrin (HPBCD)
dc.subjectTopical drug delivery
dc.subjectParticel size analysis
dc.subjectRheology analysis
dc.subjectIn vitro drug release
dc.subject.dspaceMedicine::Pharmacology
dc.titleFormulation and evaluation of a tipical preparation containing Roflumilast
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