The literature assessment explores the difficult metabolic connection that how obesity is related to insulin resistance. It begins with the aid of detailing the systematic seek strategy used to collect applicable literature, followed by way of an evidence of the choice manner and criteria for evaluating the first-rate of the selected research. The overview then delves into the pathophysiology of weight problems, elucidating elements consisting of adipose tissue dysfunction, chronic infection, and metabolic dysregulation. Similarly, it examines the underlying mechanisms of insulin resistance, which include the insulin signaling pathway, genetic predispositions, and mobile disorder. Central to the dialogue is the affiliation among obesity and insulin resistance, highlighting how extra adiposity contributes to metabolic disorder and the improvement of insulin resistance. Specifically, it explores the function of continual low-grade inflammation and adipose tissue disorder on this courting. Furthermore, the review investigates specific molecular pathways linking obesity to insulin resistance, drawing insights from population-based totally research. Finally, it evaluates pharmacotherapy options for dealing with weight problems and insulinresistance, which include medicinal drugs like liraglutide, naltrexone-bupropion, lorcaserin, phentermine-topiramate, and orlistat.